In histopathology, the presence and distribution of inflammatory mediators can provide significant insights into the nature and progression of inflammatory diseases. For example, elevated levels of IL-6 and TNF-α are often observed in chronic inflammatory conditions like rheumatoid arthritis. Histamine release can be identified by the presence of degranulated mast cells in tissues. Understanding the types and roles of these mediators helps in diagnosing and devising therapeutic strategies for various inflammatory disorders.
