Inflammatory mediators are produced by a variety of cells, including endothelial cells, leukocytes (such as neutrophils and macrophages), mast cells, and platelets. For instance, cytokines like tumor necrosis factor-alpha (TNF-α) and interleukins (ILs) are primarily produced by macrophages and T cells. Histamine is mainly released by mast cells and basophils, while prostaglandins and leukotrienes are synthesized by nearly all nucleated cells.
