Inflammatory mediators function by binding to specific receptors on target cells, leading to various cellular responses. For example, cytokines like IL-1 and TNF-α can induce the expression of adhesion molecules on endothelial cells, facilitating the migration of leukocytes to the site of injury. Chemokines such as CXCL8 (IL-8) direct the movement of immune cells towards the site of inflammation. Histamine increases vascular permeability, allowing immune cells and plasma proteins to access the affected tissue.
