In histological studies, pericyte loss can be detected using various techniques: - Immunohistochemistry (IHC): Pericyte-specific markers such as PDGFR-β and NG2 can be used to visualize pericytes. - Electron Microscopy: Provides detailed images of pericytes and their interactions with endothelial cells. - Confocal Microscopy: Allows for three-dimensional reconstruction of vessels and pericytes.