What is the Significance of SAHF in Aging and Disease?
SAHF are significant in the context of aging and age-related diseases. As cells accumulate damage over time, the induction of senescence and the formation of SAHF act as a protective mechanism against the propagation of potentially harmful cells. However, the accumulation of senescent cells and SAHF can also contribute to tissue dysfunction and the development of age-related pathologies, such as sarcopenia and Alzheimer's disease. Furthermore, in cancer biology, the presence of SAHF can influence the tumor microenvironment and impact tumor suppression and progression.
