Given their role in cellular senescence and disease, SAHF are considered a potential therapeutic target. Strategies to modulate SAHF formation and function could be beneficial in treating age-related diseases and cancer. For example, drugs that inhibit key players in SAHF formation, such as the histone methyltransferases, could potentially alleviate the negative effects of senescent cells. Conversely, promoting SAHF formation in cancer cells might enhance the efficacy of therapies aimed at inducing senescence and preventing tumor growth.
