How Do Lysosomal Storage Disorders Affect Different Organs?
The impact of LSDs varies depending on the type of disorder and the organs involved. Commonly affected organs include the liver, spleen, bone marrow, central nervous system, and skeletal muscle. For example, in Niemann-Pick disease, sphingomyelin accumulates in the liver and spleen, leading to organomegaly and dysfunction. In Tay-Sachs disease, the accumulation of GM2 ganglioside in neurons results in progressive neurodegeneration.
