What are Senescence Associated Heterochromatin Foci (SAHF)?
Senescence Associated Heterochromatin Foci (SAHF) are distinct nuclear structures that form in cells undergoing cellular senescence. These foci are characterized by dense, compacted regions of heterochromatin that contribute to the stable repression of proliferation-associated genes. SAHF are considered a hallmark of cellular senescence, a state where cells cease to divide and undergo significant changes in gene expression and chromatin organization.
