What is the Significance of M2 Macrophages in Chronic Diseases?
M2 macrophages are implicated in various chronic diseases due to their role in tissue remodeling and immune regulation. In conditions like fibrosis, excessive activation of M2 macrophages can lead to abnormal tissue repair and scarring. In cancer, tumor-associated macrophages (TAMs) often exhibit an M2-like phenotype, contributing to tumor growth and immune evasion. Understanding the behavior of M2 macrophages in these contexts is crucial for developing therapeutic strategies.
