Neurotransmitters play a crucial role in mediating the effects of CBT. Histological studies have shown that CBT can lead to changes in the levels of key neurotransmitters such as serotonin, dopamine, and glutamate. These chemical messengers are vital for mood regulation, reward processing, and cognitive functions. By normalizing neurotransmitter levels, CBT can help alleviate symptoms of mental health disorders like depression and anxiety.