The primary function of NTRK3 is to mediate the effects of its ligand, neurotrophin-3 (NT-3). Upon binding to NT-3, the TrkC receptor undergoes dimerization and autophosphorylation, which activates various intracellular signaling pathways. These pathways include the MAPK/ERK pathway, PI3K/AKT pathway, and PLCĪ³ pathway, all of which contribute to neuronal survival, differentiation, and synaptic plasticity.
