psen2

What is PSEN2?

PSEN2, or Presenilin 2, is a protein encoded by the PSEN2 gene located on chromosome 1. It is a crucial component of the gamma-secretase complex, which plays a significant role in the cleavage of various transmembrane proteins, including the amyloid precursor protein (APP). This cleavage process is vital in the generation of beta-amyloid peptides, which are implicated in the pathology of Alzheimer’s disease.

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