IL-1 is implicated in various diseases, particularly those involving chronic inflammation. Conditions such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis are associated with elevated levels of IL-1. In these diseases, IL-1 contributes to the ongoing inflammatory process, leading to tissue damage and disease progression. Targeting IL-1 with specific inhibitors has shown promise in treating these conditions, highlighting its critical role in disease pathology.
