GSDs are classified based on the specific enzyme deficiency and the affected tissue. They are commonly divided into ten main types, each associated with different enzymatic defects:
1. Type I (Von Gierke Disease): Deficiency in glucose-6-phosphatase. 2. Type II (Pompe Disease): Deficiency in acid alpha-glucosidase. 3. Type III (Cori Disease): Deficiency in debranching enzyme. 4. Type IV (Andersen Disease): Deficiency in branching enzyme. 5. Type V (McArdle Disease): Deficiency in muscle phosphorylase. 6. Type VI (Hers Disease): Deficiency in liver phosphorylase. 7. Type VII (Tarui Disease): Deficiency in muscle phosphofructokinase. 8. Type IX: Deficiency in phosphorylase kinase. 9. Type X: Deficiency in phosphoglycerate mutase.
