Histologically, IL-1 has profound effects on various tissues. In the context of inflammation, IL-1 can induce structural changes in the affected tissues. For instance, in chronic inflammatory conditions, IL-1 can lead to the recruitment of immune cells, vascular changes, and tissue remodeling. In the extracellular matrix, IL-1 can stimulate the production of matrix metalloproteinases (MMPs), which degrade extracellular matrix components, facilitating tissue repair and remodeling but also contributing to tissue damage if unchecked.
