In histological studies, IL-1 can be detected using various techniques. Immunohistochemistry (IHC) is a common method that involves using antibodies specific to IL-1 to visualize its presence in tissue sections. This technique allows researchers to localize IL-1 within specific cell types and tissue regions. Other methods include enzyme-linked immunosorbent assay (ELISA) and western blotting, which can quantify IL-1 levels in tissue extracts.