The clinical significance of RARs is underscored by their involvement in various diseases and therapeutic applications. In dermatology, retinoic acid and its derivatives are used to treat acne, psoriasis, and photoaging due to their ability to modulate keratinocyte proliferation and differentiation. Furthermore, in oncology, retinoic acid is employed in the treatment of APL, where it induces the differentiation of malignant promyelocytes into mature granulocytes.
