How Do RARs Influence Cell Differentiation and Proliferation?
RARs modulate cell differentiation by regulating the transcription of target genes involved in cell cycle control and differentiation pathways. In the hematopoietic system, RARs are essential for the differentiation of myeloid cells, and their dysfunction can lead to hematological disorders such as acute promyelocytic leukemia (APL). Additionally, in the epidermis, RARs control keratinocyte differentiation and proliferation, maintaining skin integrity and function.
