RARs are ubiquitously expressed across various tissues, albeit with differential expression patterns. RAR-α is predominantly found in the skin, immune system, and respiratory tract, while RAR-β is mainly expressed in the central nervous system, liver, and kidney. RAR-γ, on the other hand, is highly expressed in the skin and skeletal system. The tissue-specific distribution of RARs underscores their specialized roles in maintaining tissue homeostasis and function.
