Hurler Syndrome, also known as Mucopolysaccharidosis Type I (MPS I), is a rare genetic disorder caused by a deficiency of the enzyme α-L-iduronidase. This enzyme is crucial for the degradation of glycosaminoglycans (GAGs), specifically dermatan sulfate and heparan sulfate. The deficiency leads to the accumulation of these substances in various tissues and organs, resulting in progressive cellular damage.
