Addressing limited sensitivity involves several strategies:
1. Advanced Imaging Techniques: Utilizing advanced imaging modalities such as confocal microscopy and electron microscopy can provide higher resolution images, allowing for the detection of finer details.
2. Molecular Techniques: Incorporating molecular techniques like immunohistochemistry and fluorescence in situ hybridization (FISH) can enhance the detection of specific proteins and genetic abnormalities that are not visible with standard staining.
3. Digital Pathology: Digital pathology and image analysis software can assist in identifying subtle changes by providing quantitative data and reducing observer variability.
4. Training and Standardization: Continuous education and training for pathologists, along with standardization of protocols, can improve the detection rates of subtle histological changes.
