What Histological Techniques are Used to Study Synaptic Alterations?
Several histological techniques are employed to study synaptic alterations. Immunohistochemistry is commonly used to visualize specific proteins associated with synapses, such as synaptophysin and postsynaptic density protein 95 (PSD-95). Electron microscopy provides detailed images of synaptic structures at a high resolution. Additionally, confocal microscopy allows for the three-dimensional reconstruction of synaptic networks.
