How Do Synaptic Alterations Contribute to Disease Pathology?
Synaptic alterations are a hallmark of many neurological and psychiatric disorders. In Alzheimer's disease, for example, the accumulation of amyloid-beta plaques and tau tangles disrupts synaptic function, leading to cognitive decline. In schizophrenia, synaptic pruning during adolescence may be excessive, resulting in reduced synaptic density. Understanding these alterations can provide insights into disease mechanisms and potential therapeutic targets.
