What Histological Changes Can Be Observed Due to DNA Methylation?

Histological changes due to DNA methylation are often associated with alterations in tissue architecture and cellular morphology. For example, in cancer, hypermethylation of genes involved in cell cycle regulation can lead to uncontrolled cell proliferation and disrupted tissue organization. Immunohistochemical staining for methylated DNA can reveal areas of differential methylation within tissues, providing insights into the epigenetic landscape of various diseases.