What is the Relationship Between DNA Methylation and Cancer?
Aberrant DNA methylation is a hallmark of cancer. Hypermethylation of tumor suppressor genes can lead to their silencing, thereby promoting tumorigenesis. Conversely, global hypomethylation can result in genomic instability and the activation of oncogenes. Detecting these methylation changes in histological samples can aid in the diagnosis, prognosis, and potential treatment of cancer.
