Dysfunction in chordin expression or activity can lead to a variety of developmental disorders. For instance, overexpression of chordin can result in excessive inhibition of BMP signaling, leading to defects in bone and cartilage formation. Conversely, insufficient chordin activity can result in enhanced BMP signaling, causing issues such as neural tube defects and improper axis formation. Therefore, the precise regulation of chordin and BMP signaling is vital for normal embryonic development.
