What is the Role of Chordin in Tissue Differentiation?
The regulation of BMP signaling by chordin is crucial for the proper differentiation of various tissues. For example, during neural development, the inhibition of BMPs by chordin is necessary for the induction of neural tissues from the ectoderm. In the absence of chordin, BMP signaling would promote the formation of epidermal tissues instead of neural tissues. Similarly, chordin plays a role in the formation of the dorsal-ventral axis by establishing gradients of BMP activity.
