Chordin functions by binding to BMPs, such as BMP-2 and BMP-4, in the extracellular space. This binding prevents BMPs from engaging their receptors on the cell surface, thereby inhibiting the BMP signaling pathway. The inhibition of BMP signaling by chordin is essential for the proper patterning of tissues during embryogenesis. In the absence of chordin, BMP activity would not be regulated, leading to improper tissue differentiation and developmental anomalies.
