Several challenges can complicate the assessment of tissue damage in histology:
Artifacts: These are distortions or changes that occur during tissue processing and can mimic or obscure true tissue damage. Common artifacts include shrinkage, tearing, and folding of the tissue. Sampling Error: This occurs when the tissue sample is not representative of the entire organ or lesion, leading to inaccurate assessment. Inter-observer Variability: Differences in interpretation between pathologists can lead to inconsistent assessments of tissue damage.
