What are the Therapeutic Applications Targeting Hedgehog Signaling?
Given the critical role of Hedgehog signaling in development and disease, targeting this pathway has therapeutic potential. For example, inhibitors of Smoothened (Smo) are being developed and used to treat cancers associated with aberrant Hedgehog signaling. These inhibitors aim to block the activation of the Hedgehog pathway, thereby inhibiting the growth and proliferation of cancer cells.
