The selection process for aptamers is known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX). This iterative process involves the incubation of a large library of random-sequence oligonucleotides with the target of interest. Binding sequences are then separated from non-binding sequences, amplified, and subjected to further rounds of selection to enrich for high-affinity aptamers. This process can be fine-tuned to enhance the specificity and affinity of aptamers for their targets.
