What are the Implications of Dysregulated Hedgehog Signaling?
Dysregulation of Hedgehog signaling can lead to various developmental disorders and diseases. For instance, mutations in the components of the Hedgehog pathway can result in congenital anomalies such as holoprosencephaly and polydactyly. Moreover, aberrant Hedgehog signaling is implicated in the pathogenesis of several cancers, including basal cell carcinoma and medulloblastoma.
