Sample Preparation: Tissue samples are fixed and sectioned to prepare them for analysis. The sections are then mounted on glass slides. Probe Hybridization: Fluorescently labeled DNA probes are applied to the tissue sections. The samples are then incubated to allow the probes to hybridize to the target DNA sequences. Detection: After hybridization, excess probes are washed away, and the slides are examined under a fluorescence microscope. The bound probes emit fluorescence, which can be detected and analyzed.