What are the potential side effects of ADT from a histological perspective?

From a histological perspective, the side effects of ADT can include not only changes in the prostate but also in other tissues. For example, bone histology may show increased porosity and decreased density, leading to osteoporosis. Adipose tissue may increase as muscle mass decreases, reflecting the metabolic changes induced by reduced androgen levels. Histologically, these changes can be observed as increased fat deposition and reduced muscle fiber size.