How does ADT affect tissues at the histological level?

At the histological level, ADT leads to significant changes in the tissues of the prostate and other androgen-sensitive organs. The reduction in androgen levels results in decreased stimulation and growth of epithelial cells in the prostate gland. This can cause atrophy, characterized by a reduction in cell size and number. Additionally, there may be an increase in apoptosis (programmed cell death) and a reduction in glandular tissue, which histologically presents as a decrease in the density of glandular structures.