What are the histological changes observed in the prostate after ADT?

Histological analysis of prostate tissue post-ADT often reveals several changes. These include:

Glandular atrophy: The glandular epithelium becomes less prominent, and the glands themselves may shrink.
Increased apoptosis: There is a higher rate of cell death among both epithelial and stromal cells.
Fibrosis: The connective tissue within the prostate may increase, leading to a more fibrotic appearance.
Inflammatory infiltrates: There may be an increase in inflammatory cells, which can be a response to the tissue damage and cellular changes induced by ADT.