What are the Pathological Implications of IGF Dysregulation?
Dysregulation of IGF signaling pathways can lead to various pathological conditions. For instance, overexpression of IGF-1 has been implicated in cancer progression due to its role in cell proliferation and anti-apoptotic effects. On the other hand, insufficient IGF-1 levels can result in impaired growth and development, as seen in growth hormone insensitivity syndromes.
