IGFs have significant clinical implications. Elevated levels of IGF-1 are associated with conditions such as acromegaly, characterized by excessive growth of bones and tissues. Conversely, low levels of IGF-1 are linked to short stature and growth deficiencies. IGFs also play a role in cancer biology, as they can promote tumor growth and metastasis. Understanding their histological distribution and function can aid in developing therapeutic strategies for these conditions.
