What are the mechanisms of BPA-induced histological changes?
The mechanisms underlying BPA-induced histological changes are multifaceted. BPA can induce oxidative stress by generating reactive oxygen species (ROS), which can damage cellular components such as lipids, proteins, and DNA. This oxidative damage can trigger inflammatory pathways, leading to tissue remodeling and fibrosis. Moreover, BPA can interfere with gene expression and epigenetic modifications, further contributing to histological abnormalities.
