pathological angiogenesis

What are the Key Molecular Players in Pathological Angiogenesis?

Several molecular factors are involved in pathological angiogenesis. Vascular Endothelial Growth Factor (VEGF) is one of the most critical pro-angiogenic factors. Others include Fibroblast Growth Factor (FGF), Platelet-Derived Growth Factor (PDGF), and angiopoietins. These factors promote the proliferation and migration of endothelial cells, which form the lining of new blood vessels. On the flip side, thrombospondin and endostatin are examples of anti-angiogenic factors that inhibit these processes.

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