What are the Challenges in Targeting Pathological Angiogenesis?
One of the main challenges in targeting pathological angiogenesis is the complexity of the angiogenic process. Many signaling pathways are involved, and compensatory mechanisms can often bypass the inhibition of a single target. Additionally, distinguishing between pathological and physiological angiogenesis is challenging, as some level of angiogenesis is necessary for normal tissue function and repair. This necessitates the development of selective therapies that target pathological processes without disrupting normal angiogenesis.
