What Are the Histological Features of Specific GI Conditions?
Gastritis: - Characterized by inflammation of the stomach lining. - Histology shows infiltration of inflammatory cells, particularly neutrophils and lymphocytes. - Chronic gastritis may show glandular atrophy and intestinal metaplasia.
Celiac Disease: - Triggered by an immune response to gluten. - Histological features include villous atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes.
Crohn's Disease: - A type of IBD that can affect any part of the GI tract. - Histology reveals transmural inflammation, granulomas, and fissures.
Ulcerative Colitis: - Another type of IBD confined to the colon and rectum. - Histological findings include continuous mucosal inflammation, crypt abscesses, and loss of goblet cells.
Barrett's Esophagus: - A complication of chronic gastroesophageal reflux disease (GERD). - Histology shows the replacement of squamous epithelium with columnar epithelium containing goblet cells.
