There are several critical checkpoints in the cell cycle where cell cycle arrest can occur:
G1 Checkpoint: This is the primary point at which the cell decides whether to proceed with division. It assesses DNA integrity and the cellâs overall health. S Phase Checkpoint: During the synthesis phase, this checkpoint ensures that DNA replication is proceeding correctly without errors. G2 Checkpoint: Before entering mitosis, this checkpoint verifies that DNA replication has been completed successfully and that any damage has been repaired. M Checkpoint (Spindle Assembly Checkpoint): This checkpoint ensures that all chromosomes are properly aligned and attached to the spindle fibers before the cell proceeds with division.
