What is the Relationship between Early Endosomes and Disease?
Dysfunction in early endosome trafficking and sorting can lead to various diseases. For instance, defects in the endocytic pathway have been implicated in neurodegenerative diseases such as Alzheimer's disease, where disrupted endosome function can affect the processing of amyloid precursor protein (APP). Additionally, certain pathogens exploit early endosomes to enter cells and evade the immune system, highlighting their importance in infectious diseases.
