What are the implications of mTORC1 dysregulation in tissues?
Dysregulation of mTORC1 can lead to various tissue pathologies. For instance, in the liver, hyperactivation of mTORC1 can contribute to hepatocellular carcinoma by promoting uncontrolled cell proliferation. In adipose tissue, excessive mTORC1 activity can lead to obesity and insulin resistance. Moreover, in the brain, altered mTORC1 signaling is associated with neurodegenerative diseases such as Alzheimer's disease and tuberous sclerosis complex.
