Under the microscope, cryptococcoma shows a mix of inflammatory cells, including macrophages, multinucleated giant cells, lymphocytes, and plasma cells. The yeast cells of Cryptococcus appear as round to oval structures with a prominent capsule. The capsule stains positively with Mucicarmine and negatively with H&E, creating a clear halo around the yeast cells. Necrotic areas and fibrosis may also be present, along with calcifications in chronic lesions.
