How is Thyroglobulin Involved in Thyroid Hormone Production?
When the thyroid gland is stimulated by thyroid-stimulating hormone (TSH) from the pituitary gland, the iodinated thyroglobulin is endocytosed back into the follicular cells. Within the cells, the iodinated thyroglobulin undergoes proteolytic cleavage to release T4 and T3. These hormones are then secreted into the bloodstream where they exert their metabolic effects on target tissues.
