Histological diagnosis of cryptococcoma involves tissue biopsy followed by staining techniques. Hematoxylin and Eosin (H&E) staining reveals granulomas with central necrosis and encapsulated yeast cells. Special stains such as Mucicarmine, Periodic Acid-Schiff (PAS), and Gomori Methenamine Silver (GMS) are used to highlight the polysaccharide capsule of Cryptococcus species, making them more visible under the microscope.
