What are the Common Stains Used in Histology to Identify Neuronal Degeneration?
Several stains are used to identify and study neuronal degeneration in histological samples. Hematoxylin and Eosin (H&E) staining is a commonly used method to highlight general tissue structure and cell morphology. Silver stains, such as Bielschowsky stain, are used to visualize neurofibrillary tangles and amyloid plaques in Alzheimer's disease. Luxol Fast Blue is utilized to stain myelin, which can be helpful in identifying demyelination associated with neuronal degeneration. Immunohistochemistry using antibodies against specific proteins, such as beta-amyloid, alpha-synuclein, and TDP-43, can also be employed to detect neuronal inclusions.
