What are the Histological Features of Neuronal Degeneration?

Histologically, neuronal degeneration is characterized by certain distinctive features. These include the presence of neuronal inclusions, vacuolation, neuronal loss, and gliosis. Neuronal inclusions are abnormal aggregates of proteins that can be found in the cell bodies, axons, or dendrites of neurons. Vacuolation refers to the formation of vacuoles within neurons, indicating a degenerative process. Neuronal loss is often observed as a reduction in the number of neurons in affected areas. Gliosis is the proliferation of glial cells in response to neuronal damage.